Fresh analysis suggests that patients who stop using popular GLP-1 drugs like semaglutide or tirzepatide may regain lost weight far faster than those who end traditional diet and exercise programs.
Findings released in a leading health publication shows that while overweight people can lose about a fifth of their total mass while on the medication, the weight is regained at an estimated rate of 0.8 kg per month once they quit.
"People using such medications need to be aware of the potential of quick weight regain when the treatment ends," stated researcher Dr. Susan Jebb.
This pace of regain implies a return to original weight in about a year and a half.
Weighing Approaches
The study, which reviewed dozens of trials involving thousands of patients, compared the outcomes of these new drugs with older methods.
The team emphasize that individuals who shed pounds through lifestyle changes alone generally experience a less rapid weight regain—around 0.1 kg a month—once they finish.
The Reason for the Rapid Regain
Nutrition scientists believe the way of the drugs is key to understanding the heightened rebound.
GLP-1 drugs mimic a natural hormone called glucagon-like peptide-1, which moderates feelings of fullness.
"Long-term administration of GLP-1 concentrations several times higher than normal could lead to the system to generate a reduced amount of its endogenous hormone, and may also reduce sensitivity to its actions," explained Dr. Adam Collins, a dietetics expert.
"Stopping of this GLP-1 'fix' leads to hunger is no longer kept in check, making binge eating a significant risk."
An Ongoing Condition?
Medical guidelines recommend the injections for individuals with obesity-related medical conditions, alongside recommended diet and exercise modifications.
Many experts contend that, given the high risk of weight regain, the treatment should be considered ongoing.
This view is supported by pharmaceutical companies, who note that the findings "emphasize the long-term nature of excess weight," similar to managing diseases like diabetes.
Patient Experiences
Users who have discontinued the jabs report a sudden return of cravings.
"It felt as if a trigger that goes on and you're instantly extremely hungry," said a patient.
The struggle is worsened if individuals have not adopted permanent dietary or behavioural changes during treatment.
Widespread Interest
Recent estimates suggest that a significant number of people in the UK have tried these injections in the last 12 months, with desire continuing to grow.
- Use is higher among females than males.
- The middle-aged age group shows the highest level of interest.
- A large proportion obtain the medications through private prescriptions rather than the NHS.
Ultimately, experts caution that while these medications are effective agents for weight loss, they are not a standalone fix and maintained weight loss hinges on integrated behavioural changes.
